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Data source: VAERS (Vaccine Adverse Event Reporting System)

Data through 2026 · Updated quarterly

Built by TheDataProject.ai · © 2026 VaccineWatch

Important: VAERS accepts reports of adverse events following vaccination. For any given report, there is no certainty that the reported event was caused by the vaccine. Reports may contain information that is incomplete, inaccurate, coincidental, or unverifiable. Most reports to VAERS are voluntary, which means they are subject to biases. This data cannot be used to determine if vaccines cause or contribute to adverse events.

⚠️

Important: VAERS reports alone cannot determine if a vaccine caused an adverse event. Reports may contain incomplete, inaccurate, or unverified information. Correlation does not equal causation.

  1. Home
  2. Vaccine Side Effects
  3. DTaP Vaccine
6 min read
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DTaP Vaccine Side Effects

DTaP protects children against diphtheria, tetanus, and pertussis (whooping cough). Given as a 5-dose series between ages 2 months and 6 years, it's one of the most frequently administered childhood vaccines — and one of the most reported in VAERS.

93,278
Total Reports
2,414
Deaths Reported
9,116
Hospitalizations
37,224
ER Visits
ℹ️ Historical context: The older DTP (whole-cell pertussis) vaccine had higher reactogenicity and was replaced by DTaP (acellular pertussis) in the late 1990s. VAERS data includes both, and many early reports reflect the older, more reactive formulation.

Most Commonly Reported Side Effects

The following symptoms are most frequently reported after DTaP vaccination:

#1Pyrexia
16,011
#2Injection site erythema
15,414
#3Injection site swelling
8,523
#4Erythema
7,318
#5Injection site oedema
6,374
#6Injection site warmth
5,853
#7Vomiting
5,394
#8Rash
5,273
#9Urticaria
4,953
#10Injection site pain
4,760
#11Convulsion
4,183
#12Injection site induration
3,964

DTaP vs DTP: A Critical Distinction

The original DTP vaccine used whole pertussis bacteria and was associated with higher rates of fever, fussiness, and rare neurological events. The modern DTaP uses purified (acellular) pertussis components and has a significantly improved safety profile.

When looking at VAERS data, it's important to separate pre-1997 DTP reports from modern DTaP reports. The 2,414 death reports across both formulations largely reflect the older vaccine and the era before improved infant health monitoring.

Expected Side Effects

Common (up to 50% of doses):

  • Fussiness and irritability (very common in infants)
  • Pain, redness, or swelling at injection site
  • Fever (mild to moderate)
  • Decreased appetite
  • Drowsiness

Less common:

  • Vomiting
  • Extensive limb swelling (usually with 4th or 5th dose)
  • Persistent crying lasting 3+ hours

Rare:

  • Febrile seizures
  • High fever (>105°F)
  • Hypotonic-hyporesponsive episodes (sudden limpness)
  • Severe allergic reaction

Co-Administration Context

DTaP is almost always given alongside other vaccines (Hib, IPV, PCV13, hepatitis B, rotavirus) at the 2, 4, and 6-month visits. This means many VAERS reports listing DTaP also list other vaccines — making it impossible to attribute symptoms to DTaP alone from VAERS data.

⚠️ Remember: VAERS reports show correlation, not causation. Many death reports in infants reflect SIDS and other causes that occurred after vaccination by coincidence, not because of the vaccine. Always consult your healthcare provider for medical advice.

Explore This Data

DTaP Vaccine Detail →
Full VAERS profile
Pediatric Analysis →
Children's vaccine data
Tdap Side Effects →
Adult booster version

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