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Data source: VAERS (Vaccine Adverse Event Reporting System)

Data through 2026 · Updated quarterly

Built by TheDataProject.ai · © 2026 VaccineWatch

Important: VAERS accepts reports of adverse events following vaccination. For any given report, there is no certainty that the reported event was caused by the vaccine. Reports may contain information that is incomplete, inaccurate, coincidental, or unverifiable. Most reports to VAERS are voluntary, which means they are subject to biases. This data cannot be used to determine if vaccines cause or contribute to adverse events.

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Important: VAERS reports alone cannot determine if a vaccine caused an adverse event. Reports may contain incomplete, inaccurate, or unverified information. Correlation does not equal causation.

  1. Home
  2. Vaccine Side Effects
  3. Flu Vaccine
6 min read
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Flu Vaccine Side Effects

Influenza vaccines are among the most widely administered vaccines in the U.S., with hundreds of millions of doses given annually. Here's what VAERS data shows about reported side effects.

236,441
Total Reports
All flu types
11
Flu Vaccine Types
In VAERS database
2,040
Deaths Reported
14,733
Hospitalizations

Understanding the Flu Vaccine Landscape

The flu vaccine is unique in VAERS because it has been tracked continuously for over 35 years with annual administration to hundreds of millions of Americans. This provides one of the most robust baselines in the entire VAERS database for understanding normal adverse event reporting patterns.

Most Common Flu Vaccine Side Effects

The most frequently reported side effects from flu vaccines are consistent with known, expected reactions:

#1Pyrexia
16,290
#2Pain
15,508
#3Injection site pain
14,863
#4Injection site erythema
14,184
#5Pain in extremity
12,284
#6Erythema
10,340
#7Injection site swelling
9,961
#8Headache
9,501
#9Dizziness
8,105
#10Pruritus
8,016
#11Chills
7,960
#12Nausea
7,608

Types of Flu Vaccines in VAERS

VAERS tracks several different flu vaccine formulations. The main types include:

  • FLU3 (Trivalent): Protects against 3 flu strains — the traditional formulation
  • FLU4 (Quadrivalent): Protects against 4 strains — now the standard
  • FLUN (Nasal spray): Live attenuated vaccine given nasally
  • FLUA (Adjuvanted): Enhanced formulation for elderly patients
  • FLUC (Cell-based): Grown in cell culture instead of eggs
  • FLUR (Recombinant): Made without flu virus or eggs
TypeReportsDeathsHosp.
FLU3119,6951,0818,325
FLU452,1113022,421
FLUX32,8164912,538
FLUC48,85230204
FLUN36,73949586
FLUA44,18443266
FLUN43,46717154
FLUR43,4071086
FLUA33,1671087
FLUC31,689762
FLUR331404

Expected vs Concerning Side Effects

Common and expected (usually resolve in 1-2 days):

  • Soreness, redness, or swelling at injection site
  • Low-grade fever
  • Headache and muscle aches
  • Fatigue
  • Nausea

Rare but serious (seek medical attention):

  • Guillain-Barré Syndrome (GBS) — estimated 1-2 additional cases per million vaccinated
  • Severe allergic reaction (anaphylaxis) — extremely rare
  • High fever lasting more than 48 hours

Flu Vaccine and Older Adults

Adults 65 and older are recommended to receive enhanced flu vaccine formulations that may produce stronger immune responses and, correspondingly, more noticeable side effects:

  • High-dose flu vaccine (Fluzone HD): Contains 4x the antigen of standard-dose vaccines. More local reactions (soreness, redness) but significantly better protection in seniors
  • Adjuvanted flu vaccine (Fluad): Contains MF59 adjuvant to boost immune response. May cause more injection site reactions
  • Recombinant flu vaccine (Flublok): Made without eggs or live virus. Similar side effect profile to standard vaccines

The higher VAERS death reporting rate for flu vaccines reflects the elderly population that receives them, not the vaccine's safety profile. Elderly adults have high baseline mortality rates, and temporal coincidence with vaccination is expected. See our analysis of the 65+ age group for more context.

Egg Allergies and Flu Vaccines

Most flu vaccines are produced using eggs, which historically raised concerns for people with egg allergies. Current CDC guidance states that people with egg allergies can receive any age-appropriate flu vaccine without additional precautions beyond the standard 15-minute observation period. For those with severe egg allergies, cell-based (Flucelvax) and recombinant (Flublok) options are available that do not use eggs in production.

Flu vs COVID Vaccine Reports

Comparing flu and COVID vaccine VAERS reports is a common but misleading exercise. COVID vaccines had dramatically higher reporting rates due to mandatory reporting requirements, heightened public awareness, and the emergency use context. Our COVID vs Flu comparison explores this in detail.

The flu shot is recommended annually for nearly everyone over 6 months old. See where it fits on the CDC vaccine schedule and our 2026 vaccine schedule analysis.

Explore Flu Vaccine Data

Trivalent Flu (FLU3) →
Full VAERS profile
Quadrivalent Flu (FLU4) →
Full VAERS profile
COVID vs Flu Comparison →
Side-by-side analysis
COVID Vaccine Side Effects →
Compare to flu data

Frequently Asked Questions

Can the flu shot give me the flu?
No. Injectable flu vaccines contain inactivated virus and cannot cause influenza. Mild symptoms after the shot (fatigue, low-grade fever) are signs of your immune system responding, not actual flu infection. The nasal spray contains weakened live virus but also cannot cause true flu.
Why do I need a flu shot every year?
Influenza viruses mutate rapidly, and the dominant strains change each season. The annual vaccine is reformulated to match the strains most likely to circulate that year. Additionally, immunity from the flu vaccine wanes over several months.
When is the best time to get a flu shot?
September or October is ideal for most people, providing protection through the peak flu season (December–February). Getting vaccinated later is still beneficial — flu activity can persist into May.
Can I get the flu shot and COVID vaccine at the same time?
Yes. CDC allows co-administration of flu and COVID vaccines. Side effects may be slightly more noticeable but are generally the same as getting either vaccine alone. See our multi-vaccine analysis.

More Side Effect Guides

All Vaccine Side Effects
Overview across all vaccines
COVID-19 Side Effects
1.1M+ reports analyzed
Pneumonia Vaccine
Often given with flu vaccine
Reporting context: Flu vaccines have one of the longest track records in VAERS, with data spanning the full 35-year history of the system. Annual administration to hundreds of millions of people provides a robust baseline for comparison. When evaluating flu vaccine VAERS data, remember that the elderly population receiving high-dose formulations has higher baseline rates of serious health events, which inflates severity metrics for flu vaccines compared to vaccines given primarily to young, healthy populations.